Medical Research

Frequently Asked Questions

What are secretagogues?

Secretagogues are substances that induce endocrine secretions from glands. Secretagogues may be amino acids or peptides. GH secretagogues are oral or topical agents that produce a physiologic pattern of GH release unlike GH injections, which are pharmacological agents that supply high doses of synthetic GH that, over time, might actually reduce the body’s natural production, release and activity of GH. Oral GH secretagogues may be sold over the counter as nutritional supplements unlike GH injections, which are classified as drugs.

How do secretagogue supplements work?

Secretagogues may either stimulate the hypothalamus to release GH releasing factors, which causes the pituitary gland to secrete stored growth hormone or they may have a direct action on pituitary release of GH. The reason secretagogues work is because the pituitary gland continues producing growth hormone as we age, but it gradually loses its ability to release the growth hormone with advancing age. Secretagogues assist the body in maintaining GH secretion through physiologic mechanisms. Secretagagogue use also avoids the reduction in natural GH production and release that occurs when high doses of growth hormones are given by injection. Since the pituitary is stimulated to release GH naturally, secretagogues are less likely to shut down pituitary growth hormone production.

What does the combination of secretagogues in a science-based nutraceutical GH therapy rejuvenation oral formula do?

The most effective science-based GH therapy oral formulas include a combination of a GH releasing hexapeptide, such as GHRP-2, along with the amino acids glycine, lysine, arginine, glutamine and tyrosine to create a much higher concentration of released GH than either the amino acids or the hexapeptide alone could be expected to produce.

What are amino acids?

Amino acids are the smaller building block components of both peptide and protein polymers (chains). Amino acids are necessary for the synthesis of peptides, structural proteins and enzymes. The genes of all organisms code for only 20 different amino acids, although enzyme facilitated reactions can change a common amino acid into an altered compound called a derived amino acid. Amino acids can be divided into essential and nonessential groups. Essential amino acids must be obtained from the diet, whereas the body can synthesize nonessential amino acids.

Amino acids used in science-based GH formulas:

Amino acid supplementation has been found to stimulate GH releasing factors and GH release. Amino acids alone and in combination have been used as GH releasers for several decades. In fact, a high dose of the amino acid arginine is actually used by Endocrinologists as a clinical test to check for GH release by the pituitary. Italian researchers in 1981 found that an oral combination of 1,200 mg of lysine and 1,200 mg of arginine given to young male volunteers was 10 times more effective in releasing GH than taking arginine alone. The amino acid glutamine is also very effective in releasing GH in both young and old individuals.

An effective science-based nutraceutical GH therapy should include arginine, lysine and several other amino acids because these have been found to be synergistic in promoting GH release. Lysine also is a critical building block for proteins especially collagen, which is necessary for skin repair. Arginine has been found to enhance GH release by directly enhancing pituitary response to GHRH and indirectly by interfering with somatostatin inhibition of pituitary GH release. Arginine supplementation also improves exercise performance.

Glutamine, the most abundant free amino acid in the body, has been found to have an anabolic effect on skin and muscle growth in both human and animal studies making it useful for repairing aged and damaged tissues. Glutamine improves organ function and is a necessary nutrient for the health of the intestinal lining, protein synthesis, glutathione synthesis and immune function. Glutamine can help improve immune function, since it is a fuel used by white blood cells. Glutamine supplementation also increases GH release. In addition by helping repair the intestinal lining glutamine over time can also improve the absorption of other nutrients.

Glycine and arginine are converted in the body to the energy storage molecule creatine. Creatine is used by the body as fuel during physical activity. Glycine supplementation has been found to increase GH release. Glycine also increases cardiac output during exercise.

Tyrosine is an amino acid precursor to three important brain neurotransmitters epinephrine, norepinephrine and dopamine as well as the thyroid hormone thyroxin. The reason tyrosine is included in science-based GH formulas is because these three neurotransmitters are believed to have a role in regulating GH production and release.

GABA (gamma aminobutyric acid) is a natural brain neurotransmitter that has been found to pass into the brain when given orally. GABA has numerous roles in the brain, but it is included in science-based GH formulas because GABA has been found to increase GH release.

Pyroglutamate is a naturally occurring amino acid found in fruits and vegetables. When given orally, it easily passes the blood-brain barrier. In the brain pyroglutamate stimulates mental processes especially memory and learning. Pyroglutamate supplementation has been reported to reduce age related memory loss.

Vicia faba major (broad bean) extract is a natural source of L-dopa, an amino acid derivative that is a natural GH releaser. L-dopa is a precursor of the neurotransmitter dopamine, a natural growth hormone releaser. The location of action of dopamine is in the brain, but oral dopamine is not able to pass into the brain through the blood-brain barrier. On the other hand oral sources of L-dopa are able to enter the brain where the L-dopa is subsequently converted to dopamine. L-dopa was first identified in the seedlings, pods and beans of Vicia faba in 1913. Since that time, a number of anecdotal cases of symptomatic improvement in Parkinson’s disease have been reported in the medical literature after the ingestion of Vicia faba or Vicia faba extracts.

Why are arginine and other amino acids included in a science-based nutraceutical GH therapy oral formula?

Arginine is an essential amino acid that is not produce by the body, so it must be obtained from foods or supplements. Arginine acts to increase GH secretion via inhibition of hypothalamic somatostatin release and stimulation of GH release by the pituitary. Arginine, lysine, glycine, glutamine and tyrosine are included in the most effective science-based nutraceutical GH therapy oral formulas because they synergistically potentiate the GH response to the anterior pituitary hexapeptide (GHRP-2).

What are peptides and proteins?

Peptides are chains of amino acids and proteins are longer chains of defined sequence. Every peptide and protein has a special and unique sequence of amino acids, which is known as its primary structure. Hexapeptides are chains composed of six amino acids.

What is IGF-1?

IGF-1 is Insulin-like Growth Factor 1. IGF-1 is also known as Somatomedin-C. Once a pulse of GH is released by the pituitary gland, some of the GH binds to liver GH receptors causing the liver to secrete a polypeptide known as somatomedian or insulin-like growth factor, which like GH also has powerful growth promoting properties. IGF-1 has a longer duration of action than GH and it has a greater affinity for muscle-cell receptors. IGF-1 is responsible for the anabolic action of GH by stimulating RNA and protein production in muscle and other tissues of the body. IGF-1 belongs to a family of substances secreted by the cells of the body called growth factors. Other growth factors in this group are epidermal, platelet derived, fibroblastic, transforming, and nerve growth factors.

Why do some natural science- based rejuvenation oral formulas contain Novel Polyose Complex and effervescence?

The intestinal absorption of low molecular weight peptides is increased by effervescence and the presence of glucose polymers when they are present in the intestinal tract at the same time as the anterior pituitary peptides (GHRP-2), which is why a science-based formula should include all of these compounds in the formula. Effervescence increases small intestinal absorption of many compounds. In order to maximize the absorption of the ingredients in an oral science-based nutraceutical rejuvenation formula, it is essential that the formula be taken on an empty stomach and only with water.

What are GH Releasing Peptides?

GH secretagogues, as a group, work by direct stimulation of the pituitary to release GH, however some members of this group known as GH releasing peptides (GHRPs) also have an effect on the hypothalamus.

GH releasing peptides (GHRP) such as GHRP-2 act by stimulating GHRH release from the hypothalamus, inhibiting somatostatin activity and have independent effects that include direct stimulation of GH release from the pituitary gland separate from the action of GHRH.

Dr. Cyril Y. Bowers, the Director of Endocrinology and Metabolism at Tulane University Medical School discovered GHRP-6 (Growth hormone Releasing Peptide-6), a D-amino acid hexapeptide, which led to the identification of a new pituitary receptor opening the door on a new approach to growth hormone therapy. This receptor when stimulated is capable of initiating pulsatile GH secretion in GH deficient older individuals when GH secretion has declined.

GHRP-6 was the first hexapeptide to be used in humans. GHRP-6 is a synthetic hexapeptide, which stimulates a dosage-related release of GH. This peptide has the potential of inducing GH release via a direct pituitary site of action. The discovery in 1984 by Dr. Bowers of GHRP-6 led his research team to the discovery of other hexapeptides with the potential to induce GH release by direct pituitary action such as growth hormone releasing peptide-2, also known as GHRP-2, which is perhaps the best hexapeptide for use in a science-based rejuvenation formulation.

Growth hormone releasing peptide-2 (GHRP-2) is a synthetic peptide that is a second-generation GH releasing peptide (GHRP) that stimulates GH secretion. This GHRP is two to three times more potent than the original GHRP-6 that was synthesized by Dr. Bowers. GHRP-2 appears to act through the pituitary receptor for GHRH at least partially and it may also act through a different pituitary receptor to directly stimulate GH release from the pituitary. In fact GHRP-2 may be even more effective than GHRH in stimulating pituitary release of GH.

The reason GHRP-2 is best for a science-based formula is because the GH-releasing activity of GHRP-2 is effective even with oral administration. Studies show that the GH releasing effect of GHRP-2 will undergo partial desensitization during continuous infusion, but much less during intermittent oral administration, which is one reason that a science-based formula would be most effective when given in on and off cycles.

GHRPs like GHRP-2 are hexapeptides that possess significant, dose-related GH-releasing effects even after oral administrations. GHRP-2 works by causing an increase of the amount of GHRH released by the hypothalamus, which in turn, causes an increase in GH release by the anterior pituitary and by direct action on pituitary receptors causing a release of GH. Extended use of GHRP-2 also increases IGF-1 levels. Typically, only a small amount of a given oral dose of GHRP-2 is absorbed in the gastrointestinal tract, however, only micrograms of GHRP-2 are needed to create a significant GH release from the pituitary.

GHRP-2 is equivalent to GHRH in terms of its ability to stimulate GH release from bovine, sheep and rat pituitary cells. GHRP-2 is reported to be the most potent GHRP. Prolonged administration of oral GHRP-2 increases IGF-1 levels both in animals and in humans.

In summary growth hormone-releasing peptides (GHRPs) are a group of synthetic peptides that have been found to have potent stimulatory effects on pituitary GH secretion in both animals and humans. GHRP’s such as GHRP-2 act on specific receptors that may be present either at the pituitary or the hypothalamic level or both. Some researchers believe that GHRPs have a dual action by counteracting the activity of somatostatin at both the pituitary and the hypothalamic level and by mimicking GHRH’s activity of stimulating pituitary GH release.

The most effective science-based GH formulations should include the amino acids known to stimulate GH release from the pituitary as well as special hexapeptides such as GHRP-2, which is even more effective than GHRH in releasing GH from the pituitary. The combination of these amino acids with GHRP-2 causes a synergistic GH releasing effect.

How can I maximize the effect of a rejuvenation program?

The most important things any individual can do are to eat properly, maintain optimal body weight, exercise regularly and get sufficient sleep.

1. Diets generally should be balanced with 30-40% protein, 20% fat and 40-50% carbohydrate. Refined sugars and processed carbohydrates should be avoided. It is important to instead consume complex carbohydrates and proteins that digest slowly. The purchase of a book on whole foods from a bookstore to learn the right types of foods to eat is advisable. In addition, give at least two hours between your last meal and bedtime. GH is released in pulses through out the day with the highest release in the early hours of sleep, and in the third and fourth hours after meals.

2. Maintain an optimum body weight. GH production declines in obesity. To maintain your natural production of GH keep your weight down.

3. Regular exercise especially weight training for 45-minutes to 1 hour 3 to 4 times a week has been shown to increase levels of GH.

4. Restful sleep of at least 7-8 hours per night is one of the most important factors in promoting normal GH secretion during sleep. Growing teenagers and individuals recovering from illness may need 10-12 hours of sleep per night.

What does a science-based nutraceutical GH and peptide rejuvenation program do to the skin?

Skin care consumers and physicians should consider the benefits of using a combination of science-based oral GH enhancing supplements and topical skin serums that contain fibroblastic growth factors, boron and vitamin C. The combined use of both oral and topical formulas has shown the ability to tighten skin, reduce wrinkles, reduce cellulite, and increase muscle mass, enhance performance and reduce body fat. Other benefits of this type of third generation GH therapy includes: deeper and more refreshing sleep, increased growth of hair, nails and skin, improvement in sexual performance and symptoms associated with degenerative diseases such as arthritis and fibromyalgia (a condition that involves chronic muscular pain), improvement in metabolism of sugar and fats, elevation of mood, enhanced strength and stamina, and an overall increase in the sense of well-being. Many consumers find that they are most pleased with their improvement in memory, concentration, motivation and reduction of symptoms associated with stress and psychological burnout.

How long before I see results from a natural science-based rejuvenation program?

Some users begin to see results within four to six weeks. However these programs should be administered for several months in order to truly begin to see all their positive effects. When an individual combines both an oral science-based GH therapy formula and a topical skin formula, they may begin to see improved facial tone and less facial wrinkles within 4-8 weeks. Physical changes in the body take time to emerge and it is critically important to recognize that the purpose of taking a formula that improves GH activity in the body is for ongoing long-term maintenance and improvement. In general, the higher your initial GH level is, the longer it will take to see a difference, but individuals with a low initial GH level may start seeing results within a few weeks. Such a formula, when the program is followed according to manufacturer’s directions, overtime may create significant differences in your health, appearance, performance and outlook.

In the first month individuals may experience increased energy, strength and stamina, improved sleep, improved stress tolerance, sexual energy and a sense of greater well being. The second month of use generally begins to produce a firming up of skeletal muscles, some reduction of fat, improved skin tone and reduced facial puffiness. By this time many individuals may also begin to experience improving memory, concentration and learning. The third month of use will generally produce a clear improvement in lean muscle shape, tone and mass, further loss of fat, further improvement in facial features with improving skin elasticity and reduction in facial wrinkles. Beyond the third month of use these conditions keep on improving as the anti-aging effects of the program continue to manifest.

How long can I safely take a science-based nutraceutical rejuvenation program?

A science-based rejuvenation program is completely safe when taken long-term. Unlike GH injections, a science-based nutraceutical GH therapy formula, when taken as directed, will not shut down the body’s natural GH production. The medical advisors of science-based nutraceutical GH therapy programs generally recommend that the oral formulas are best used in cycles of three months, followed by 2-4 weeks off of the oral formula so that the body does not start an inhibitory feedback loop and negate the product’s effectiveness. During the three month “on” cycle, it is recommended that science-based GH therapy oral formulas be taken in the recommended pattern of 5 days on and 2 days off, so the body can continually maintain its normal GH releasing pattern.

Who should use a science-based nutraceutical rejuvenation program?

Science-based GH therapy programs are indicated for adults who want an effective GH enhancing program.

Are the results from a science-based nutraceutical GH rejuvenation program permanent?

A science-based nutraceutical rejuvenation program assists the body in reducing fat, increasing lean body mass and improving facial appearance when the programs are used long-term as directed. Unfortunately, when the program is stopped the body’s GH output resumes its age related decline. It is best to think about science-based GH therapy rejuvenation as a maintenance program designed to assist the body in fighting the ravages of aging much like providing recommended levels of oil in your car to protect and reduce wear on the engine. No rejuvenation program can stop all related changes, but science-based GH rejuvenation formulas can certainly help you retain youthful vigor and beauty longer than you would without it. Clinical research suggests that growth hormone augmentation should be sustained on a continuous basis after age 35.

Why are science-based nutraceutical rejuvenation programs (oral and topical combinations) formulated to address GH receptor and insulin issues?

Excessive blood insulin levels, found in the majority of modern older adults, also interrupt the communication between GH and its cell receptor counterpart. The combined effect is the decline in physical and mental function that so scares many individuals afraid of the decline in appearance, health, and functionality that is the result of aging. An anti-aging program of GH rejuvenation therefore must effectively address GH release from the pituitary, GH receptor sensitivity and insulin issues if it is to truly work, which must be the main goal of any anti-aging program. The most effective science-based rejuvenation oral preparations would include Novel Polyose complex to address the receptor and insulin issues.

Can a science-based nutraceutical rejuvenation oral formulas help with weight loss?

Clinical research has shown that obese individuals have reduced secretion of GH. It is known that GH therapies that supply GH by injection or by oral GH secretagogues can decrease total body fat. A science-based nutraceutical rejuvenation oral formula that includes multiple synergistic GH releasing agents, when used along with exercise can have a very beneficial effect on obese individuals.

When is the best time to take a science-based nutraceutical rejuvenation oral formula for maximizing growth hormone activity?

A science-based nutraceutical rejuvenation oral formula is best taken on an empty stomach before bed at least three to four hours after food. Nighttime use of a science-based rejuvenation oral formula augments the natural peak release of GH, which occurs during the first 90 minutes of sleep. For individuals who cannot refrain from snacking before bedtime then the first thing in the morning is also an acceptable time to use the formula because morning insulin levels are low after 6-8 hours without food. In order to maximize the effects of the morning dose of these formulas, food and dietary supplements must be avoided for one to two hours after ingestion of the oral formula. Enhancement of muscle building and fat burning will also occur if an individual exercises within 1-2 hours after taking the morning dose.

Why are science-based nutraceutical rejuvenation oral formulas used 5 days on and 2 days off?

Longitudinal observation has determined that short breaks from using an oral science-based rejuvenation formula maintains its effectiveness by maintaining receptor efficiency, which helps prevent GH receptor down regulation.

What if I am taking medications or other nutritional products?

Generally, science-based nutraceutical rejuvenation oral formulas will not interfere with medications or other nutrient supplements as long as the medicines or nutritional products are not taken at the same time. These formulas must be taken on an empty stomach to achieve their maximal effect, since other compounds can interfere with the absorption of some of the ingredients.

Are there any contraindications for use of a science-based nutraceutical rejuvenation formula?

The only reports of negative reactions from use of science-based nutraceutical formulas are in individuals who are intolerant to citric acid, which may be included in the formula. However, if you are pregnant, nursing, or have a serious ailment, you should seek and follow the advice of your healthcare provider, but in general, a science-based nutraceutical rejuvenation formula should not be used while pregnant or nursing. Children should not use a science-based nutraceutical formula because most children are still making sufficient quantities of GH.

I have heard that GH supplementation can have some negative side effects, is this also true with a science-based nutraceutical rejuvenation program?

Oral science-based nutraceutical rejuvenation formulas do not contain GH. Instead these preparations naturally enhance the body’s ability to produce its own GH so that GH production can return to a more youthful level. This approach is similar to enhancing your own production of estrogen rather than resorting to estrogen supplementation during menopause.

How does a science-based nutraceutical rejuvenation formula improve the oral bioavailability of the active ingredients?

The best oral science-based nutraceutical formula should include features that aid in delivery of its secretagogues into the body. The inclusion of effervescence, Novel Polyose complex, and Vicia faba major creates a chaperone system that prevents the premature destruction of active ingredients in the digestive tract before they can be absorbed. These ingredients also facilitate absorption of the formula’s active ingredients. The bicarbonate in an effervescent formula helps to temporarily reduce stomach acidity, which helps protect the amino acids and the pituitary secretagogue (GHRP-2) from the effects of stomach acids as they transit into the small intestine where they are absorbed.

Why should an oral science-based nutraceutical rejuvenation program include effervescence in its formula?

Effervescent powders confer certain advantages to oral science-based nutraceutical rejuvenation formulas. Effervescence enhances the absorption of a wide range of substances and is actively used by the pharmaceutical industry and many nutrient manufacturers because of this effect. Formulators of oral science-based GH supplements have found that effervescence can be used in combination with other absorption enhancers in order to increase the rate and amount of absorption of active secretagogues. Effervescent powders are a naturally buffered source of electrolytes that do not cause gastric upset. Studies have shown that the body readily utilizes effervescence formulas and effervescence can shorten residence time in the stomach while speeding up the rate of absorption. Use of a powder promotes rapid entry into solution, temporary stomach pH neutralization, and assimilation of the ingredients contained in the formula.

What are the benefits to skin care professionals of a science-based nutraceutical rejuvenation oral supplement and topical skin serum combination?

Because the FDA classifies GH enhancement supplements as nutritional products, doctors, skin care professionals and spas often offer them to their clients. Clients are generally well satisfied when they have positive improvements in their appearance and sense of well being, and are also quite happy with an effective GH rejuvenation program that costs only a tiny fraction of the amount charged for GH injections.

Oral science-based nutraceutical GH rejuvenation programs increase blood levels of GH and IGF-1. Most importantly these combinations have a synergistic action in promoting vital skin proteins such as collagen and elastin, which are needed for youthful skin tone, wrinkle reduction and thickening of thin aged skin.

Is it necessary to have an exercise regimen when I am on a science-based nutraceutical rejuvenation formula?

Exercise stimulates muscle growth, the burning of fat and increases the circulating levels of GH, IGF-1 and other growth factors. Exercise is very important for everyone and science-based rejuvenation formulas that boost GH and growth factor levels will greatly enhance the results received from exercise. People who are in very poor physical condition and do not maintain a healthy lifestyle, which includes daily exercise, are unlikely to receive the full benefits of a science-based nutraceutical rejuvenation program.


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